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KMID : 0665420220370030248
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Korean Journal of Food Culture
2022 Volume.37 No. 3 p.248 ~ p.255
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Inhibitory Effect of Fermented Spanish Extract on Inorganic phosphate-induced Vascular Calcification in ex vivo Aortic Rings
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Lee Sang-Hee
Hong Sun-Mi
Sung Mi-Jung
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Abstract
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Spinach (Spinacia oleracea L.), a green leafy vegetable, is well known as a functional food due to its biological activities.
Vascular calcification is associated with several disease conditions including atherosclerosis, diabetes, and chronic kidneydisease (CKD), and is known to raise the risk of cardiovascular diseases related morbidity and mortality. However, there areno previous studies that have investigated the effects of fermented spinach exract (FSE) against aortic and its underlyingmechanisms. Therefore, this study investigated the effects and action of possible mechanisms of FSE on inorganicphosphate (PI)-induced vascular calcification in ex vivo mouse aortic rings. PI increased vascular calcification throughcalcium deposition in ex vivo aortic rings. FSE inhibited calcium accumulation and osteogenic key marker, runt-relatedtranscription factor 2 (Runx2), and bone Morphogenetic Protein 2 (BMP-2) protein expression in ex vivo aortic rings. And,FSE inhibited PI-induced extracellular signal-regulated kinase (ERK) and p38 phosphorylation in ex vivo aortic rings. Theseresults show that FSE can prevent vascular calcification which may be a crucial way for the prevention and treatment ofvascular disease association with vascular calcification.
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KEYWORD
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Vascular calcification,, fermented spanish extracts, calcium accumulation, osteogenic differentiation protein
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